Drug interactions
Glycopyrronium + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Glycopyrronium and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glycopyrronium and umeclidinium are antimuscarinics, so combining them duplicates therapy and adds anticholinergic effects including dry mouth, urinary retention, constipation, tachycardia and raised intraocular pressure.
What this interaction means in plain words
Glycopyrronium and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid using two antimuscarinics together and use only one. If both are in use, monitor for anticholinergic effects such as urinary retention and glaucoma symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Glycopyrronium and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both glycopyrronium and umeclidinium are antimuscarinics, so combining them duplicates therapy and adds anticholinergic effects including dry mouth, urinary retention, constipation, tachycardia and raised intraocular pressure.
How serious is the interaction between Glycopyrronium and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antimuscarinics together and use only one. If both are in use, monitor for anticholinergic effects such as urinary retention and glaucoma symptoms.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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