Drug interactions
Glycopyrronium + Umeclidinium bromide
Severity: Moderate
Glycopyrronium and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block muscarinic receptors, and glycopyrronium given orally or parenterally is absorbed systemically and may add to the effects of inhaled umeclidinium. This raises the risk of dry mouth, urinary retention, constipation, tachycardia and narrow-angle glaucoma worsening.
What this interaction means in plain words
Glycopyrronium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use of multiple antimuscarinics where possible. Monitor for urinary retention, raised intraocular pressure and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Glycopyrronium with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Glycopyrronium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents block muscarinic receptors, and glycopyrronium given orally or parenterally is absorbed systemically and may add to the effects of inhaled umeclidinium. This raises the risk of dry mouth, urinary retention, constipation, tachycardia and narrow-angle glaucoma worsening.
How serious is the interaction between Glycopyrronium and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of multiple antimuscarinics where possible. Monitor for urinary retention, raised intraocular pressure and constipation.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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