Drug interactions
Glycopyrronium tosylate + Hydroxyzine
Severity: Minor
Glycopyrronium tosylate and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has anticholinergic properties, and topical glycopyrronium tosylate can be absorbed systemically to a small degree. Together they may add to anticholinergic effects such as dry mouth, blurred vision, urinary retention and constipation.
What this interaction means in plain words
Glycopyrronium tosylate and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic activity.
What to do
Monitor for anticholinergic symptoms and reduce use of the topical agent or hydroxyzine if they emerge. Take particular care in older patients and those with glaucoma or urinary retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glycopyrronium tosylate and Hydroxyzine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Glycopyrronium tosylate with Hydroxyzine?
MediHelp rates the interaction as minor. Glycopyrronium tosylate and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine has anticholinergic properties, and topical glycopyrronium tosylate can be absorbed systemically to a small degree. Together they may add to anticholinergic effects such as dry mouth, blurred vision, urinary retention and constipation.
How serious is the interaction between Glycopyrronium tosylate and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and reduce use of the topical agent or hydroxyzine if they emerge. Take particular care in older patients and those with glaucoma or urinary retention.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
