Drug interactions
Glycopyrronium tosylate + Ipratropium
Severity: Moderate
Glycopyrronium tosylate and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate has some systemic absorption, and its labeling warns about additive anticholinergic effects with other antimuscarinics. Combined with ipratropium, this can cause dry mouth, urinary retention, constipation and blurred vision.
What this interaction means in plain words
Glycopyrronium tosylate and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic effects and discontinue glycopyrronium if they become troublesome. Avoid use in patients with urinary retention or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Glycopyrronium tosylate with Ipratropium?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate has some systemic absorption, and its labeling warns about additive anticholinergic effects with other antimuscarinics. Combined with ipratropium, this can cause dry mouth, urinary retention, constipation and blurred vision.
How serious is the interaction between Glycopyrronium tosylate and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and discontinue glycopyrronium if they become troublesome. Avoid use in patients with urinary retention or narrow-angle glaucoma.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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