Drug interactions
Glycopyrronium tosylate + Perphenazine
Severity: Moderate
Glycopyrronium tosylate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium tosylate is a topical product applied to the skin for hyperhidrosis, with some systemic absorption. Combined with perphenazine, additive anticholinergic effects such as dry mouth, urinary retention, blurred vision and constipation can occur.
What this interaction means in plain words
Glycopyrronium tosylate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for systemic anticholinergic adverse effects, especially in older patients. Stop the topical product if urinary retention, visual disturbance or marked confusion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Glycopyrronium tosylate with Perphenazine?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium tosylate is a topical product applied to the skin for hyperhidrosis, with some systemic absorption. Combined with perphenazine, additive anticholinergic effects such as dry mouth, urinary retention, blurred vision and constipation can occur.
How serious is the interaction between Glycopyrronium tosylate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic anticholinergic adverse effects, especially in older patients. Stop the topical product if urinary retention, visual disturbance or marked confusion develops.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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