Drug interactions
Gold sodium thiomalate + Imidapril
Severity: Moderate
Gold sodium thiomalate and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors given with injectable gold have caused nitritoid reactions, with flushing, nausea, vomiting and hypotension. The reaction is uncommon but may occur shortly after gold injection.
What this interaction means in plain words
Gold sodium thiomalate and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; it may involve vasodilatory effects, with ACE inhibition potentiating gold-induced reactions.
What to do
Monitor patients for flushing and hypotension after gold injections. Consider an alternative antihypertensive if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Gold sodium thiomalate with Imidapril?
MediHelp rates the interaction as moderate. Gold sodium thiomalate and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with injectable gold have caused nitritoid reactions, with flushing, nausea, vomiting and hypotension. The reaction is uncommon but may occur shortly after gold injection.
How serious is the interaction between Gold sodium thiomalate and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for flushing and hypotension after gold injections. Consider an alternative antihypertensive if reactions recur.
What other medicines interact with Imidapril?
MediHelp also lists interactions of Imidapril with, for example, Amiloride, Eplerenone, Lithium. The full list is on the Imidapril page.
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