Drug interactions
Granisetron + Lithium
Severity: Moderate
Granisetron and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can cause T-wave changes, sinus node dysfunction and occasional QT prolongation, particularly at toxic levels. Granisetron may add a modest QT effect.
What this interaction means in plain words
Granisetron and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Lithium belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction.
What to do
Monitor serum lithium levels and electrolytes, and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Watch for syncope or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Granisetron with Lithium?
MediHelp rates the interaction as moderate. Granisetron and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium can cause T-wave changes, sinus node dysfunction and occasional QT prolongation, particularly at toxic levels. Granisetron may add a modest QT effect.
How serious is the interaction between Granisetron and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum lithium levels and electrolytes, and obtain an ECG in patients with cardiac disease or other QT-prolonging drugs. Watch for syncope or palpitations.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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