Drug interactions
Granisetron + Romidepsin
Severity: Moderate
Granisetron and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with QT/ECG changes, and granisetron is often used for its nausea. Combined use may increase risk of arrhythmia, especially with low potassium or magnesium.
What this interaction means in plain words
Granisetron and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Check and correct potassium and magnesium before each romidepsin dose and obtain an ECG in patients with cardiac risk factors. Consider an alternative antiemetic in patients with long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Frequently asked questions
Can I take Granisetron with Romidepsin?
MediHelp rates the interaction as moderate. Granisetron and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with QT/ECG changes, and granisetron is often used for its nausea. Combined use may increase risk of arrhythmia, especially with low potassium or magnesium.
How serious is the interaction between Granisetron and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before each romidepsin dose and obtain an ECG in patients with cardiac risk factors. Consider an alternative antiemetic in patients with long QT.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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