Drug interactions
Granisetron + Selegiline transdermal
Severity: Moderate
Granisetron and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO inhibitor and serotonin syndrome has been reported when 5-HT3 antagonists are combined with serotonergic drugs. The risk with granisetron is uncertain and probably low, but the potential severity warrants awareness.
What this interaction means in plain words
Granisetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; MAO inhibition reduces serotonin breakdown.
What to do
Monitor for agitation, clonus, hyperthermia and autonomic instability after starting. Stop the agents and give supportive care if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Frequently asked questions
Can I take Granisetron with Selegiline transdermal?
MediHelp rates the interaction as moderate. Granisetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO inhibitor and serotonin syndrome has been reported when 5-HT3 antagonists are combined with serotonergic drugs. The risk with granisetron is uncertain and probably low, but the potential severity warrants awareness.
How serious is the interaction between Granisetron and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, clonus, hyperthermia and autonomic instability after starting. Stop the agents and give supportive care if serotonin syndrome is suspected.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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