Drug interactions
Granisetron + Venlafaxine
Severity: Moderate
Granisetron and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported with 5-HT3 antagonists combined with serotonergic antidepressants such as venlafaxine. Venlafaxine can also have a small QT effect. The absolute risk is low.
What this interaction means in plain words
Granisetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Granisetron belongs to Gastrointestinal Tract; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, with possible minor additive QT effects.
What to do
Co-use is acceptable when needed; monitor for agitation, tremor, clonus, sweating and fever. Check an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Granisetron with Venlafaxine?
MediHelp rates the interaction as moderate. Granisetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported with 5-HT3 antagonists combined with serotonergic antidepressants such as venlafaxine. Venlafaxine can also have a small QT effect. The absolute risk is low.
How serious is the interaction between Granisetron and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-use is acceptable when needed; monitor for agitation, tremor, clonus, sweating and fever. Check an ECG if other QT risk factors are present.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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