Drug interactions
Grapefruit + Losartan
Severity: Minor
Grapefruit and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4 and may alter losartan conversion to its active metabolite. Reported effects on losartan exposure are small and clinical impact is usually negligible.
What this interaction means in plain words
Grapefruit and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents altering losartan metabolism.
What to do
No routine change is needed; monitor blood pressure if large amounts of grapefruit juice are consumed regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Grapefruit with Losartan?
MediHelp rates the interaction as minor. Grapefruit and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4 and may alter losartan conversion to its active metabolite. Reported effects on losartan exposure are small and clinical impact is usually negligible.
How serious is the interaction between Grapefruit and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure if large amounts of grapefruit juice are consumed regularly.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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