Drug interactions
Grapefruit + Solifenacin
Severity: Minor
Grapefruit and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may modestly raise solifenacin exposure. The effect is usually small and clinically minor.
What this interaction means in plain words
Grapefruit and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit furanocoumarins.
What to do
No restriction is usually required; advise patients to report increased anticholinergic effects if they consume large amounts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Grapefruit with Solifenacin?
MediHelp rates the interaction as minor. Grapefruit and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may modestly raise solifenacin exposure. The effect is usually small and clinically minor.
How serious is the interaction between Grapefruit and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No restriction is usually required; advise patients to report increased anticholinergic effects if they consume large amounts.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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