Drug interactions
Green tea + Midazolam
Severity: Minor
Green tea and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The caffeine in green tea may modestly reduce the sedative effect of midazolam. The effect is usually small and of limited clinical importance.
What this interaction means in plain words
Green tea and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Green tea belongs to Gastrointestinal Tract; Midazolam belongs to Central Nervous System.
Why it happens
Caffeine antagonizes adenosine receptors, opposing benzodiazepine-induced sedation.
What to do
No routine change needed; titrate midazolam to clinical effect if sedation is inadequate in heavy caffeine consumers.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Green tea
- Adenosine + Green tea Moderate
- Benzphetamine + Green tea Moderate
- Bortezomib + Green tea Moderate
- Dextroamphetamine + Green tea Moderate
- Diethylpropion + Green tea Moderate
- Ephedrine + Green tea Moderate
Frequently asked questions
Can I take Green tea with Midazolam?
MediHelp rates the interaction as minor. Green tea and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The caffeine in green tea may modestly reduce the sedative effect of midazolam. The effect is usually small and of limited clinical importance.
How serious is the interaction between Green tea and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; titrate midazolam to clinical effect if sedation is inadequate in heavy caffeine consumers.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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