Drug interactions
Griseofulvin + Methoxsalen
Severity: Moderate
Griseofulvin and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause photosensitivity, so combined use may intensify phototoxic reactions such as severe sunburn or blistering. This is particularly relevant during PUVA therapy.
What this interaction means in plain words
Griseofulvin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing pharmacodynamic effects.
What to do
Avoid combining where possible, or reduce UV exposure and adjust the PUVA dose. Counsel on strict photoprotection and monitor the skin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Griseofulvin with Methoxsalen?
MediHelp rates the interaction as moderate. Griseofulvin and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause photosensitivity, so combined use may intensify phototoxic reactions such as severe sunburn or blistering. This is particularly relevant during PUVA therapy.
How serious is the interaction between Griseofulvin and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or reduce UV exposure and adjust the PUVA dose. Counsel on strict photoprotection and monitor the skin.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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