Drug interactions
Griseofulvin + Prednisone
Severity: Minor
Griseofulvin and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak CYP3A4 inducer and may increase prednisolone clearance, potentially reducing corticosteroid effect. The clinical significance is generally small.
What this interaction means in plain words
Griseofulvin and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Prednisone belongs to Endocrine.
Why it happens
Weak induction of hepatic CYP3A4 increases prednisolone metabolism.
What to do
Monitor for loss of disease control and increase the prednisone dose if clinical response diminishes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Prednisone?
MediHelp rates the interaction as minor. Griseofulvin and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak CYP3A4 inducer and may increase prednisolone clearance, potentially reducing corticosteroid effect. The clinical significance is generally small.
How serious is the interaction between Griseofulvin and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control and increase the prednisone dose if clinical response diminishes.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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