Drug interactions
Griseofulvin + Propafenone
Severity: Moderate
Griseofulvin and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower propafenone concentrations and reduce antiarrhythmic efficacy.
What this interaction means in plain words
Griseofulvin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Propafenone belongs to Cardiovascular.
Why it happens
CYP3A4 induction by griseofulvin may increase propafenone metabolism.
What to do
Monitor heart rhythm and ECG, and adjust the propafenone dose if arrhythmia control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Griseofulvin with Propafenone?
MediHelp rates the interaction as moderate. Griseofulvin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower propafenone concentrations and reduce antiarrhythmic efficacy.
How serious is the interaction between Griseofulvin and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm and ECG, and adjust the propafenone dose if arrhythmia control is lost.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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