Drug interactions
Griseofulvin + Quetiapine
Severity: Moderate
Griseofulvin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce quetiapine concentrations and lead to relapse of psychiatric symptoms. Strong CYP3A4 inducers markedly lower quetiapine exposure.
What this interaction means in plain words
Griseofulvin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Quetiapine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 accelerates quetiapine metabolism.
What to do
Monitor clinical response and increase quetiapine dose if needed. Reduce the dose again after griseofulvin is stopped to avoid excess sedation or hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Griseofulvin with Quetiapine?
MediHelp rates the interaction as moderate. Griseofulvin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce quetiapine concentrations and lead to relapse of psychiatric symptoms. Strong CYP3A4 inducers markedly lower quetiapine exposure.
How serious is the interaction between Griseofulvin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase quetiapine dose if needed. Reduce the dose again after griseofulvin is stopped to avoid excess sedation or hypotension.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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