Drug interactions
Griseofulvin + Secobarbital
Severity: Moderate
Griseofulvin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates have been reported to reduce griseofulvin absorption and may also induce its metabolism. Lower griseofulvin levels may lead to antifungal treatment failure or relapse.
What this interaction means in plain words
Griseofulvin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates may reduce oral griseofulvin absorption and induce hepatic enzymes that metabolize it.
What to do
Monitor clinical response of the fungal infection and consider a higher griseofulvin dose or an alternative antifungal if response is poor. Avoid the combination where an alternative hypnotic is feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Griseofulvin with Secobarbital?
MediHelp rates the interaction as moderate. Griseofulvin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates have been reported to reduce griseofulvin absorption and may also induce its metabolism. Lower griseofulvin levels may lead to antifungal treatment failure or relapse.
How serious is the interaction between Griseofulvin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response of the fungal infection and consider a higher griseofulvin dose or an alternative antifungal if response is poor. Avoid the combination where an alternative hypnotic is feasible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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