Drug interactions
Griseofulvin + Selexipag
Severity: Minor
Griseofulvin and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag's active metabolite is formed and cleared via CYP2C8, and strong inhibitors raise exposure. Griseofulvin is not an established CYP2C8 inhibitor, so a clinically meaningful interaction is unlikely.
What this interaction means in plain words
Griseofulvin and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Selexipag belongs to Cardiovascular.
Why it happens
Mechanism not established; CYP2C8 inhibition by griseofulvin is unproven.
What to do
No dose change is needed. Monitor for prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Griseofulvin with Selexipag?
MediHelp rates the interaction as minor. Griseofulvin and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selexipag's active metabolite is formed and cleared via CYP2C8, and strong inhibitors raise exposure. Griseofulvin is not an established CYP2C8 inhibitor, so a clinically meaningful interaction is unlikely.
How serious is the interaction between Griseofulvin and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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