Drug interactions
Griseofulvin + Sufentanil
Severity: Minor
Griseofulvin and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared mainly by CYP3A4, and griseofulvin is a weak inducer. Reduced opioid effect is possible but likely small, and sufentanil is usually titrated to effect.
What this interaction means in plain words
Griseofulvin and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Sufentanil belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase sufentanil metabolism.
What to do
Titrate sufentanil to analgesic response; if griseofulvin is stopped after prolonged use, watch for increased opioid effect and respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Griseofulvin with Sufentanil?
MediHelp rates the interaction as minor. Griseofulvin and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sufentanil is cleared mainly by CYP3A4, and griseofulvin is a weak inducer. Reduced opioid effect is possible but likely small, and sufentanil is usually titrated to effect.
How serious is the interaction between Griseofulvin and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to analgesic response; if griseofulvin is stopped after prolonged use, watch for increased opioid effect and respiratory depression.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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