Drug interactions
Griseofulvin + Tazemetostat
Severity: Moderate
Griseofulvin and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized by CYP3A4 and is itself a weak inducer. Griseofulvin may lower its exposure and reduce efficacy.
What this interaction means in plain words
Griseofulvin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Tazemetostat belongs to Miscellaneous.
Why it happens
Griseofulvin induces CYP3A4, increasing tazemetostat clearance.
What to do
Avoid combining with a moderate or strong inducer where possible; prefer an alternative antifungal and monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Tazemetostat
Frequently asked questions
Can I take Griseofulvin with Tazemetostat?
MediHelp rates the interaction as moderate. Griseofulvin and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is metabolized by CYP3A4 and is itself a weak inducer. Griseofulvin may lower its exposure and reduce efficacy.
How serious is the interaction between Griseofulvin and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with a moderate or strong inducer where possible; prefer an alternative antifungal and monitor tumor response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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