Drug interactions
Griseofulvin + Tipranavir
Severity: Minor
Griseofulvin and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is metabolized by CYP3A4 and is given with ritonavir, which counters much induction. Griseofulvin may still modestly reduce its levels.
What this interaction means in plain words
Griseofulvin and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Tipranavir belongs to Anti Virals.
Why it happens
Griseofulvin induces CYP3A4, but ritonavir co-administration largely offsets the effect.
What to do
Monitor HIV viral load during co-therapy; no empirical dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Griseofulvin with Tipranavir?
MediHelp rates the interaction as minor. Griseofulvin and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir is metabolized by CYP3A4 and is given with ritonavir, which counters much induction. Griseofulvin may still modestly reduce its levels.
How serious is the interaction between Griseofulvin and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load during co-therapy; no empirical dose change is needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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