Drug interactions
Griseofulvin + Voclosporin
Severity: Moderate
Griseofulvin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is nephrotoxic, but griseofulvin is not a recognized nephrotoxin. Griseofulvin may also weakly induce CYP3A4 and reduce voclosporin exposure, which could blunt its effect.
What this interaction means in plain words
Griseofulvin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Voclosporin belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by griseofulvin may lower voclosporin concentrations; additive nephrotoxicity is unproven.
What to do
Monitor renal function and proteinuria response in lupus nephritis, and adjust the voclosporin dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Griseofulvin with Voclosporin?
MediHelp rates the interaction as moderate. Griseofulvin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is nephrotoxic, but griseofulvin is not a recognized nephrotoxin. Griseofulvin may also weakly induce CYP3A4 and reduce voclosporin exposure, which could blunt its effect.
How serious is the interaction between Griseofulvin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and proteinuria response in lupus nephritis, and adjust the voclosporin dose per labeling.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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