Drug interactions
Griseofulvin + Ziprasidone
Severity: Minor
Griseofulvin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may modestly lower ziprasidone exposure because CYP3A4 contributes to its metabolism. The effect is likely small, since ziprasidone is mostly cleared by aldehyde oxidase.
What this interaction means in plain words
Griseofulvin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Ziprasidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase the minor oxidative metabolism of ziprasidone.
What to do
No dose change is routinely needed; monitor psychiatric symptom control if griseofulvin is given long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Griseofulvin with Ziprasidone?
MediHelp rates the interaction as minor. Griseofulvin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may modestly lower ziprasidone exposure because CYP3A4 contributes to its metabolism. The effect is likely small, since ziprasidone is mostly cleared by aldehyde oxidase.
How serious is the interaction between Griseofulvin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor psychiatric symptom control if griseofulvin is given long term.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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