Drug interactions
Guanfacine + Lorlatinib
Severity: Moderate
Guanfacine and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and can lower guanfacine concentrations, since guanfacine is cleared mainly by CYP3A4. This may reduce blood pressure or ADHD symptom control.
What this interaction means in plain words
Guanfacine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing guanfacine metabolism.
What to do
Monitor blood pressure and clinical response to guanfacine, and consider increasing the guanfacine dose if efficacy is lost. Reassess the dose when lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Lorlatinib?
MediHelp rates the interaction as moderate. Guanfacine and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and can lower guanfacine concentrations, since guanfacine is cleared mainly by CYP3A4. This may reduce blood pressure or ADHD symptom control.
How serious is the interaction between Guanfacine and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response to guanfacine, and consider increasing the guanfacine dose if efficacy is lost. Reassess the dose when lorlatinib is stopped.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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