Drug interactions
Guanfacine + Nilotinib
Severity: Moderate
Guanfacine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib can raise guanfacine concentrations through CYP3A4 inhibition. This may cause more hypotension, bradycardia and sedation.
What this interaction means in plain words
Guanfacine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guanfacine belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4-mediated metabolism of guanfacine.
What to do
Monitor blood pressure, heart rate and sedation, and reduce the guanfacine dose if adverse effects occur. Extended-release guanfacine labeling recommends halving the dose with moderate or strong CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Nilotinib?
MediHelp rates the interaction as moderate. Guanfacine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib can raise guanfacine concentrations through CYP3A4 inhibition. This may cause more hypotension, bradycardia and sedation.
How serious is the interaction between Guanfacine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and reduce the guanfacine dose if adverse effects occur. Extended-release guanfacine labeling recommends halving the dose with moderate or strong CYP3A4 inhibitors.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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