Drug interactions
Guanfacine + Repaglinide
Severity: Minor
Guanfacine and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine, a central alpha-2 agonist, may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Patients taking repaglinide may then fail to recognise low glucose early.
What this interaction means in plain words
Guanfacine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guanfacine belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Reduced sympathetic outflow dampens the catecholamine-mediated warning signs of hypoglycemia.
What to do
Counsel patients that hypoglycemia may be less obvious and encourage regular blood glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Guanfacine with Repaglinide?
MediHelp rates the interaction as minor. Guanfacine and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Guanfacine, a central alpha-2 agonist, may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Patients taking repaglinide may then fail to recognise low glucose early.
How serious is the interaction between Guanfacine and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients that hypoglycemia may be less obvious and encourage regular blood glucose monitoring.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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