Drug interactions
Guselkumab + Measles mumps and rubella vaccine
Severity: Moderate
Guselkumab and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guselkumab is an IL-23 inhibitor, and labeling advises avoiding live vaccines during treatment. Safety and response to live vaccines are not well characterized.
What this interaction means in plain words
Guselkumab and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
IL-23 blockade may modestly impair immune responses; effect on live vaccine safety is not established.
What to do
Complete live vaccinations before starting guselkumab where possible, and avoid live vaccines during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Guselkumab and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guselkumab is an IL-23 inhibitor, and labeling advises avoiding live vaccines during treatment. Safety and response to live vaccines are not well characterized.
How serious is the interaction between Guselkumab and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete live vaccinations before starting guselkumab where possible, and avoid live vaccines during treatment.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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