Drug interactions
Guselkumab + Mechlorethamine
Severity: Moderate
Guselkumab and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is a cytotoxic alkylating agent that causes myelosuppression, and guselkumab modulates immune responses through IL-23 blockade. Combined use may increase susceptibility to serious infections. Systemic exposure after topical use is minimal, so the concern is mainly with injectable use.
What this interaction means in plain words
Guselkumab and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Mechlorethamine belongs to Oncology.
Why it happens
Additive immunosuppression from cytotoxic myelosuppression and IL-23 inhibition.
What to do
Monitor for signs of infection and check blood counts during combined use. Screen for latent tuberculosis before guselkumab and treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Guselkumab with Mechlorethamine?
MediHelp rates the interaction as moderate. Guselkumab and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is a cytotoxic alkylating agent that causes myelosuppression, and guselkumab modulates immune responses through IL-23 blockade. Combined use may increase susceptibility to serious infections. Systemic exposure after topical use is minimal, so the concern is mainly with injectable use.
How serious is the interaction between Guselkumab and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts during combined use. Screen for latent tuberculosis before guselkumab and treat infections promptly.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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