Drug interactions
Guselkumab + Primidone
Severity: Minor
Guselkumab and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzymes, and IL-23 blockade may reverse this suppression. Primidone and its active metabolite phenobarbital could be affected modestly. Narrow therapeutic index warrants awareness.
What this interaction means in plain words
Guselkumab and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guselkumab belongs to Miscellaneous; Primidone belongs to Central Nervous System.
Why it happens
Cytokine modulation by IL-23 inhibition may normalize suppressed CYP450 activity, potentially altering primidone clearance.
What to do
Monitor seizure control and drug levels (primidone and phenobarbital) when guselkumab is started or stopped. Adjust the dose only if response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Guselkumab with Primidone?
MediHelp rates the interaction as minor. Guselkumab and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzymes, and IL-23 blockade may reverse this suppression. Primidone and its active metabolite phenobarbital could be affected modestly. Narrow therapeutic index warrants awareness.
How serious is the interaction between Guselkumab and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and drug levels (primidone and phenobarbital) when guselkumab is started or stopped. Adjust the dose only if response changes.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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