Drug interactions
Guselkumab + Ublituximab
Severity: Moderate
Guselkumab and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ublituximab depletes B cells, while guselkumab blocks IL-23. Used together they may increase the risk of infections, although there is no specific evidence of a combined effect.
What this interaction means in plain words
Guselkumab and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Guselkumab belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from B-cell depletion (anti-CD20) and IL-23 inhibition.
What to do
Avoid routine combination where possible; if used, monitor for signs of infection and consider the prolonged B-cell depletion effect of ublituximab when timing therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Guselkumab with Ublituximab?
MediHelp rates the interaction as moderate. Guselkumab and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ublituximab depletes B cells, while guselkumab blocks IL-23. Used together they may increase the risk of infections, although there is no specific evidence of a combined effect.
How serious is the interaction between Guselkumab and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination where possible; if used, monitor for signs of infection and consider the prolonged B-cell depletion effect of ublituximab when timing therapy.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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