Drug interactions
Haemophilus influenzae type b vaccine + Mycophenolate mofetil
Severity: Moderate
Haemophilus influenzae type b vaccine and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate may blunt antibody responses to Hib vaccine, leaving patients less protected. The vaccine is non-live and can be given safely.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of lymphocyte proliferation by mycophenolate reduces vaccine immunogenicity.
What to do
Vaccinate before starting mycophenolate when possible, and consider revaccination or serology if given during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate may blunt antibody responses to Hib vaccine, leaving patients less protected. The vaccine is non-live and can be given safely.
How serious is the interaction between Haemophilus influenzae type b vaccine and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting mycophenolate when possible, and consider revaccination or serology if given during therapy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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