Drug interactions
Haemophilus influenzae type b vaccine + Tacrolimus
Severity: Moderate
Haemophilus influenzae type b vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may reduce the antibody response to the conjugate Hib vaccine, leaving the patient with inadequate protection. The vaccine is not live, so it is safe to give.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent immune response to vaccination.
What to do
Vaccinate before immunosuppression when possible. Otherwise vaccinate and consider checking antibody response or revaccinating if immunosuppression is later reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may reduce the antibody response to the conjugate Hib vaccine, leaving the patient with inadequate protection. The vaccine is not live, so it is safe to give.
How serious is the interaction between Haemophilus influenzae type b vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before immunosuppression when possible. Otherwise vaccinate and consider checking antibody response or revaccinating if immunosuppression is later reduced.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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