Drug interactions
Haloperidol + Henbane
Severity: Moderate
Haloperidol and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with haloperidol this can increase anticholinergic toxicity such as dry mouth, urinary retention, tachycardia, constipation and confusion.
What this interaction means in plain words
Haloperidol and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects from belladonna alkaloids and haloperidol.
What to do
Avoid combined use where possible and monitor for anticholinergic toxicity, particularly in older adults. Reduce or stop the anticholinergic agent if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Henbane?
MediHelp rates the interaction as moderate. Haloperidol and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids. Combined with haloperidol this can increase anticholinergic toxicity such as dry mouth, urinary retention, tachycardia, constipation and confusion.
How serious is the interaction between Haloperidol and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible and monitor for anticholinergic toxicity, particularly in older adults. Reduce or stop the anticholinergic agent if symptoms appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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