Drug interactions
Haloperidol + Indinavir
Severity: Moderate
Haloperidol and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise haloperidol concentrations, increasing the risk of extrapyramidal symptoms, sedation and QT prolongation.
What this interaction means in plain words
Haloperidol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated haloperidol metabolism by indinavir.
What to do
Start haloperidol at a low dose and monitor for adverse effects and QTc. Reduce the haloperidol dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Indinavir?
MediHelp rates the interaction as moderate. Haloperidol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise haloperidol concentrations, increasing the risk of extrapyramidal symptoms, sedation and QT prolongation.
How serious is the interaction between Haloperidol and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start haloperidol at a low dose and monitor for adverse effects and QTc. Reduce the haloperidol dose if toxicity appears.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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