Drug interactions
Haloperidol + Infigratinib
Severity: Moderate
Haloperidol and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol may increase infigratinib exposure through CYP3A4 inhibition, potentially worsening adverse effects such as hyperphosphatemia and ocular toxicity. The effect is predicted and likely modest.
What this interaction means in plain words
Haloperidol and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Predicted inhibition of CYP3A4-mediated infigratinib metabolism by haloperidol.
What to do
Monitor for infigratinib adverse effects including serum phosphate and eye symptoms. Consider an alternative antipsychotic if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Infigratinib?
MediHelp rates the interaction as moderate. Haloperidol and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol may increase infigratinib exposure through CYP3A4 inhibition, potentially worsening adverse effects such as hyperphosphatemia and ocular toxicity. The effect is predicted and likely modest.
How serious is the interaction between Haloperidol and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infigratinib adverse effects including serum phosphate and eye symptoms. Consider an alternative antipsychotic if toxicity emerges.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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