Drug interactions
Haloperidol + Ketamine
Severity: Moderate
Haloperidol and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS depression, and together they may increase sedation and impair psychomotor function. Haloperidol is sometimes used to treat ketamine emergence phenomena, and the combination is generally manageable.
What this interaction means in plain words
Haloperidol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor level of consciousness, respiration and blood pressure when used together, especially in procedural settings. Adjust doses to the degree of sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Haloperidol with Ketamine?
MediHelp rates the interaction as moderate. Haloperidol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause CNS depression, and together they may increase sedation and impair psychomotor function. Haloperidol is sometimes used to treat ketamine emergence phenomena, and the combination is generally manageable.
How serious is the interaction between Haloperidol and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness, respiration and blood pressure when used together, especially in procedural settings. Adjust doses to the degree of sedation.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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