Drug interactions
Haloperidol + Loprazolam
Severity: Moderate
Haloperidol and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines combined with antipsychotics add to sedation, psychomotor impairment and hypotension. Risk is higher in elderly patients and with higher doses.
What this interaction means in plain words
Haloperidol and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through GABA-A potentiation and dopamine/histamine/adrenergic blockade.
What to do
Use the lowest effective doses and monitor for oversedation, falls and confusion. Avoid concurrent alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Loprazolam?
MediHelp rates the interaction as moderate. Haloperidol and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines combined with antipsychotics add to sedation, psychomotor impairment and hypotension. Risk is higher in elderly patients and with higher doses.
How serious is the interaction between Haloperidol and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, falls and confusion. Avoid concurrent alcohol and other sedatives.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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