Drug interactions
Haloperidol + Lumefantrine
Severity: Major
Haloperidol and Lumefantrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine (with artemether) prolongs the QT interval and haloperidol has a similar effect, so the combination increases the risk of torsades de pointes. Lumefantrine may also inhibit CYP2D6 and modestly raise haloperidol levels.
What this interaction means in plain words
Haloperidol and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through hERG channel blockade, plus possible CYP2D6 inhibition by lumefantrine.
What to do
Avoid the combination where feasible and consider an alternative antimalarial or antipsychotic. If unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haloperidol and Lumefantrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Lumefantrine?
MediHelp rates the interaction as major. Haloperidol and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine (with artemether) prolongs the QT interval and haloperidol has a similar effect, so the combination increases the risk of torsades de pointes. Lumefantrine may also inhibit CYP2D6 and modestly raise haloperidol levels.
How serious is the interaction between Haloperidol and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where feasible and consider an alternative antimalarial or antipsychotic. If unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
