Drug interactions
Haloperidol + Meclizine
Severity: Moderate
Haloperidol and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with anticholinergic and sedative effects that add to those of haloperidol, which may worsen drowsiness, confusion, dry mouth and urinary retention, particularly in older adults. Reduced haloperidol absorption is not well established.
What this interaction means in plain words
Haloperidol and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive anticholinergic and CNS depressant effects.
What to do
Monitor for sedation, confusion and anticholinergic effects, especially in elderly patients. Choose a non-sedating alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haloperidol and Meclizine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Haloperidol with Meclizine?
MediHelp rates the interaction as moderate. Haloperidol and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with anticholinergic and sedative effects that add to those of haloperidol, which may worsen drowsiness, confusion, dry mouth and urinary retention, particularly in older adults. Reduced haloperidol absorption is not well established.
How serious is the interaction between Haloperidol and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and anticholinergic effects, especially in elderly patients. Choose a non-sedating alternative if symptoms develop.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
