Drug interactions
Haloperidol + Methylergonovine
Severity: Minor
Haloperidol and Methylergonovine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine is a CYP3A4 substrate and haloperidol has little inhibitory effect on this enzyme, so there is no clear pharmacokinetic interaction. A serotonergic or neuroleptic malignant syndrome interaction is only theoretical.
What this interaction means in plain words
Haloperidol and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; only theoretical additive serotonergic or dopaminergic effects.
What to do
No routine adjustment is needed; be alert for agitation, hyperthermia or rigidity if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Methylergonovine?
MediHelp rates the interaction as minor. Haloperidol and Methylergonovine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylergonovine is a CYP3A4 substrate and haloperidol has little inhibitory effect on this enzyme, so there is no clear pharmacokinetic interaction. A serotonergic or neuroleptic malignant syndrome interaction is only theoretical.
How serious is the interaction between Haloperidol and Methylergonovine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be alert for agitation, hyperthermia or rigidity if both are used.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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