Drug interactions
Haloperidol + Metoclopramide intranasal
Severity: Major
Haloperidol and Metoclopramide intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block dopamine D2 receptors, so combining them increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome.
What this interaction means in plain words
Haloperidol and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid concurrent use and choose a non-dopamine-blocking antiemetic or prokinetic such as ondansetron if QT allows. If unavoidable, monitor for movement disorders and rigidity or fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Metoclopramide intranasal?
MediHelp rates the interaction as major. Haloperidol and Metoclopramide intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents block dopamine D2 receptors, so combining them increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome.
How serious is the interaction between Haloperidol and Metoclopramide intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-dopamine-blocking antiemetic or prokinetic such as ondansetron if QT allows. If unavoidable, monitor for movement disorders and rigidity or fever.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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