Drug interactions
Haloperidol + Midazolam intranasal
Severity: Moderate
Haloperidol and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol may modestly raise midazolam levels and both drugs depress the CNS. The result can be deeper or prolonged sedation and respiratory depression.
What this interaction means in plain words
Haloperidol and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus weak CYP3A4 inhibition by haloperidol reducing midazolam clearance.
What to do
Monitor sedation level and respiratory status after dosing, and avoid repeat doses until sedation has cleared. Reduce the midazolam dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Midazolam intranasal?
MediHelp rates the interaction as moderate. Haloperidol and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol may modestly raise midazolam levels and both drugs depress the CNS. The result can be deeper or prolonged sedation and respiratory depression.
How serious is the interaction between Haloperidol and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after dosing, and avoid repeat doses until sedation has cleared. Reduce the midazolam dose if excessive sedation occurs.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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