Drug interactions
Haloperidol + Mobocertinib
Severity: Major
Haloperidol and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib prolongs QT and is a CYP3A4 substrate, and haloperidol both prolongs QT and weakly inhibits CYP3A4. The combination can raise the risk of torsades de pointes and other serious arrhythmias.
What this interaction means in plain words
Haloperidol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with possible increase in mobocertinib exposure via CYP3A4 inhibition.
What to do
Avoid the combination and use an antipsychotic with less QT effect. If unavoidable, monitor ECG and electrolytes closely and reduce the mobocertinib dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Mobocertinib?
MediHelp rates the interaction as major. Haloperidol and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib prolongs QT and is a CYP3A4 substrate, and haloperidol both prolongs QT and weakly inhibits CYP3A4. The combination can raise the risk of torsades de pointes and other serious arrhythmias.
How serious is the interaction between Haloperidol and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antipsychotic with less QT effect. If unavoidable, monitor ECG and electrolytes closely and reduce the mobocertinib dose per labeling.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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