Drug interactions
Haloperidol + Nefazodone
Severity: Moderate
Haloperidol and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and may raise haloperidol concentrations, increasing extrapyramidal symptoms, sedation and QT prolongation risk. Nefazodone also has serotonergic activity.
What this interaction means in plain words
Haloperidol and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated haloperidol metabolism by nefazodone.
What to do
Start with a lower haloperidol dose and monitor for extrapyramidal symptoms, sedation and QTc prolongation. Adjust the dose according to response and ECG findings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Nefazodone?
MediHelp rates the interaction as moderate. Haloperidol and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a strong CYP3A4 inhibitor and may raise haloperidol concentrations, increasing extrapyramidal symptoms, sedation and QT prolongation risk. Nefazodone also has serotonergic activity.
How serious is the interaction between Haloperidol and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower haloperidol dose and monitor for extrapyramidal symptoms, sedation and QTc prolongation. Adjust the dose according to response and ECG findings.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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