Drug interactions
Haloperidol + Nirogacestat
Severity: Moderate
Haloperidol and Nirogacestat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is a CYP3A4 substrate, so inhibitors can increase its exposure. Haloperidol is only a weak inhibitor, so the effect is likely small but may increase diarrhea and hepatic adverse effects.
What this interaction means in plain words
Haloperidol and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Nirogacestat belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by haloperidol reducing nirogacestat clearance.
What to do
Monitor for diarrhea, liver enzyme elevations and other adverse effects. Consider dose reduction of nirogacestat if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Haloperidol with Nirogacestat?
MediHelp rates the interaction as moderate. Haloperidol and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirogacestat is a CYP3A4 substrate, so inhibitors can increase its exposure. Haloperidol is only a weak inhibitor, so the effect is likely small but may increase diarrhea and hepatic adverse effects.
How serious is the interaction between Haloperidol and Nirogacestat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, liver enzyme elevations and other adverse effects. Consider dose reduction of nirogacestat if toxicity emerges.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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