Drug interactions
Haloperidol + Orphenadrine
Severity: Moderate
Haloperidol and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant with sedative properties and is also used to treat antipsychotic extrapyramidal symptoms. Combined with haloperidol it can add to sedation, confusion and anticholinergic effects such as urinary retention, constipation and dry mouth.
What this interaction means in plain words
Haloperidol and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Use the lowest effective doses, especially in older adults, and monitor for sedation, confusion and anticholinergic toxicity. Reassess the need for orphenadrine if extrapyramidal symptoms resolve.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Orphenadrine?
MediHelp rates the interaction as moderate. Haloperidol and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant with sedative properties and is also used to treat antipsychotic extrapyramidal symptoms. Combined with haloperidol it can add to sedation, confusion and anticholinergic effects such as urinary retention, constipation and dry mouth.
How serious is the interaction between Haloperidol and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, especially in older adults, and monitor for sedation, confusion and anticholinergic toxicity. Reassess the need for orphenadrine if extrapyramidal symptoms resolve.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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