Drug interactions
Haloperidol + Propranolol
Severity: Moderate
Haloperidol and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use may produce additive hypotension, and rarely severe hypotensive reactions. Haloperidol may modestly raise propranolol levels through CYP2D6 competition, and both can contribute to QT or conduction effects.
What this interaction means in plain words
Haloperidol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects plus possible CYP2D6 inhibition reducing propranolol metabolism.
What to do
Monitor blood pressure and heart rate, particularly at initiation and dose changes. Reduce the propranolol dose if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Propranolol?
MediHelp rates the interaction as moderate. Haloperidol and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use may produce additive hypotension, and rarely severe hypotensive reactions. Haloperidol may modestly raise propranolol levels through CYP2D6 competition, and both can contribute to QT or conduction effects.
How serious is the interaction between Haloperidol and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly at initiation and dose changes. Reduce the propranolol dose if hypotension or bradycardia occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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