Drug interactions
Haloperidol + Quinacrine
Severity: Moderate
Haloperidol and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, one of the enzymes that metabolises haloperidol, potentially raising haloperidol concentrations. Higher exposure increases the risk of extrapyramidal symptoms and QT prolongation.
What this interaction means in plain words
Haloperidol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2D6 inhibition by quinacrine reducing haloperidol clearance.
What to do
Monitor for extrapyramidal effects and sedation, and consider ECG monitoring. Reduce the haloperidol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Quinacrine?
MediHelp rates the interaction as moderate. Haloperidol and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6, one of the enzymes that metabolises haloperidol, potentially raising haloperidol concentrations. Higher exposure increases the risk of extrapyramidal symptoms and QT prolongation.
How serious is the interaction between Haloperidol and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal effects and sedation, and consider ECG monitoring. Reduce the haloperidol dose if adverse effects appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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