Drug interactions
Haloperidol + Quinupristin / dalfopristin
Severity: Moderate
Haloperidol and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise haloperidol concentrations. Higher haloperidol exposure adds to its QT-prolonging and extrapyramidal effects.
What this interaction means in plain words
Haloperidol and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated haloperidol metabolism by quinupristin/dalfopristin.
What to do
Monitor the ECG and for extrapyramidal symptoms or sedation during co-treatment. Consider reducing the haloperidol dose and keep electrolytes normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Haloperidol and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise haloperidol concentrations. Higher haloperidol exposure adds to its QT-prolonging and extrapyramidal effects.
How serious is the interaction between Haloperidol and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and for extrapyramidal symptoms or sedation during co-treatment. Consider reducing the haloperidol dose and keep electrolytes normal.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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